PUBLICATIONS
Google scholar profile: https://scholar.google.co.uk/citations?user=xwFaEUYAAAAJ&hl=en
2024
68. Fritzsche M and Kruse K, Mechanical force matters in early T cell activation, PNAS, 2024.
67. Schneider F, Cespedes PF, Karedla N, Dustin ML, Fritzsche M, Quantifying biomolecular organisation in membranes with brightness-transit statistics, Nature Communications, 2024.
66. Barnkob MB, Michaels YS, André V, Macklin PS, Gileadi U, Valvo S, Rei M, Kulicke C, Chen JL, Jain V, Woodcock VK, Colin-York H, Hadjinicolaou VA, Kong Y, Mayya V, Mazet JM, Mead GJ, Bull JA, Rijal P, Pugh CW, Townsend AR, Gérard A, Olsen LR, Fritzsche M, Fulga TA, Dustin ML, Jones EY, Cerundolo V, Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells, Nature Communcations, 2024.
65. Athilingam T, Nelanuthala AVS, Breen C, Narain Karedla, Fritzsche M, Wohland T, Saunders TE, Long-range formation of the Bicoid gradient requires multiple dynamic modes that spatially vary across the embryo, Development, 2024.
2023
64. Salafranca J, Ko JK, Mukherjee AK, Fritzsche M, Grinsven E, Udalova IA, Neutrophil nucleus: shaping the past & the future, Journal of Leukocyte Biology, 2023
63. He W, Gea-Mallorquí E, Colin-York H, Fritzsche M, Gillespie GM, Brackenridge S, Borrow P, McMichael AJ, Intracellular trafficking of HLA-E and its regulation, JEM, 2023.
62. Issler M, Colin-York H, Fritzsche M, Quantifying Immune Cell Force Generation Using Traction Force Microscopy, The Immune Synapse: Methods and Protocols, Spinger US, 2023.
2022
61. Fritzsche M, Live microscopy: cracking the challenge to image biology unfolding in cells, tissues, and organs, Nature Communications Biology, 2022.
60. Cespedes PF, Jainarayanan A, Fernández-Messina L, Valvo S, Saliba DG, Kurz E, Kvalvaag A, Chen L, Ganskow C, Colin-York H, Fritzsche M, Peng Y, Dong T, Johnson E, Siller-Farfán JA, Dushek O, Sezgin E, Peacock B, Law A, Aubert D, Engledow S, Attar M, Hester S, Fischer R, Sánchez-Madrid F, Dustin DL, T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles, Nature Communications, 2022.
59. Zaccai NR, Kadlecova Z, Dickson VK, Korobchevskaya K, Kamenicky J, Kovtun O, Umasankar PK, Wrobel AG, Kaufman JG, Gray SR, Qu K, Evans PR, Fritzsche M, Sroubek F, Höning S, Briggs JA, Kelly BT, Owen DJ, Traub LM, FCHO controls AP2’s initiating role in endocytosis through a PtdIns(4,5)P2-dependent switch, Science Advances, 2022.
58. Colin-York H, Heddleston J, Wait E, Karedla N, deSantis M, Khuon S, Chew TL, Sbalzarini IF, Fritzsche M, Quantifying Molecular Dynamics within Complex Cellular Morphologies using LLSM-FRAP, Small Methods, 2022.
57. Royer C, Sandham E, Slee E, Schneider F, Lagerholm CB, Godwin J, Veits N, Hathrell H, Zhou F, Leonavicius K, Garratt J, Narendra T, Vincent A, Jones C, Child T, Coward K, Graham C, Fritzsche M, Lu X, Srinivas S, ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis, Nature Communications, 2022.
2021
56. Javanmardi Y*, Colin-York H*, Szita N, Fritzsche M, Moendarbary E, Quantifying cell-generated forces: Poisson’s ratio matters, Nature Communications Physics, 2021 (*co-first authors).
55. Korobchevskaya K, Colin-York H, Barbieri L, Fritzsche M, Extended mechanical force measurements using structured illumination microscopy, Philosophical Transactions Royal Society A, 2021.
54. Colin-York H, Quantifying nano-scale cellular force generation, Nature Device & Materials Engineering, 2021.
53. Li D*, Colin-York H*, Barbieri L*, Javanmardi Y, Guo T, Korobchevskaya K, Moendarbary E, Li D, Fritzsche M, Astigmatic Traction force
microscopy (aTFM), Nature Communications, 2021 (*co-first authors).
52. Barbieri L*, Colin-York H*, Korobchevskaya K*, Li D, Karedla N, Schneider F, Dustin M, Li D, Fritzsche M, Two-dimensional TIRF-SIM
Traction Force Microscopy (2D TIRF-SIM-TFM), Nature Communications, 2021 (*co-first authors).
51. Pfannenstill V, Barbotin A, Colin-York H, Fritzsche M, Quantitative Methodologies to Dissect Immune Cell Mechanobiology, MDPI Cells, 2021.
50. Fritzsche M, What is the right mechanical readout for understanding the mechanobiology of the immune response?, Frontiers in Cell and Developmental Biology, 2021.
49. Felce JH, Parolini, Sezgin E, Céspedes PF, Korobchevskaya K, Jones M, Peng Y, Dong T, Fritzsche M, Aarts D, Frater J, Dustin ML, Single-Molecule, Super-Resolution, and Functional Analysis of G Protein-Coupled Receptor Behavior Within the T Cell Immunological Synapse, Frontiers in Cell And Developmental Biology, 2021.
2020
48. Schneider F, Colin-York H, Fritzsche M, Quantitative bio-imaging tools to dissect the interplay of membrane and cytoskeletal actin dynamics in immune cells, Frontiers in Immunology, 2020.
47. Fritzsche M, Thinking multi-scale to advance mechanobiology, Nature Communications Biology, 2020.
46. Layton T, Williams L, Colin-York H, McCann F, Cabrita M, Feldmann M, Brown C, Xie W, Fritzsche M, Furniss D, and Nanchahal J, Single cell force profiling of human myofibroblasts reveals a biophysical spectrum of cell states, Biology Open, 2020.
45. Layton TB, Williams L, McCann F, Zhang M, Fritzsche M, Colin-York H, Cabrita M, Ng MTH, Feldmann M, Samson S, Furniss D, Xie W & Nanchahal J, Cellular census of human fibrosis defines functionally distinct stromal cell types and states, Nature Communications, 2020.
44. Sarapulov AV, Petrov P, Hernández-Pérez S, Šuštar V, Kuokkanen E, Vainio M, Cords L, Fritzsche M, Carrasco YR, Mattila PK, Missing-In-Metastasis / Metastasis Suppressor 1 regulates B cell receptor signaling, B cell metabolic potential and T cell-independent immune responses, Frontiers in Immunology, 2020.
43. Stanly TA, Fritzsche M, Banerji S, Shrestha D, Schneider F, Eggeling C, and Jackson DG, The cortical actin network regulates avidity-dependent binding of hyaluronan by the Lymphatic Vessel Endothelial receptor LYVE-1, Journal of Biological Chemistry, 2020.
42. Colin-York H, Kumari S, Barbieri L, Cords L, and Fritzsche M, Distinct actin cytoskeleton behaviour in primary and immortalised T-cells, Journal of Cell Science, 2020.
2019
41. Izadi D, Layton TB, Williams L, McCann F, Cabrita M, Espirito Santo AI, Xie W, Colin-York H, Fritzsche M, Feldmann M, Midwood K, Nanchahal J, Identification of TNFR2 and IL-33 as therapeutic targets in localized fibrosis, Science Advances, 2019.
40. Hamid MA, Colin-York H, Khalid-Alham N, Browne M, Cerundolo L, Chen JL, Yao X, Rosendo-Machado S, Waugh C, Maldonado-Perez D, Bowes E, Verrill C, Cerundolo V, Conlon CP, Fritzsche M, Peng Y, and Dong T, Self-maintaining CD103+ cancer-specific T cells are highly energetic with rapid cytotoxic and effector responses, Cancer Immunology Research, 2019.
39. Bedard M, Shrestha D, Priestman D, Wang Y, Schneider F, Matute JD, Iyer SS, Gileadi U, Prota G, Kandasamy M, Veerapen N, Besra G, Fritzsche M, Zeissig S, Shevchenko A, Christianson JC, Platt F, Eggeling C, Blumberg RS, Salio M, and Cerundolo V, Sterile activation of invariant natural killer T cells by ER-stressed antigen presenting cells, PNAS, 2019.
38. Kumari S, Colin-York H, Irvine DJ, and Fritzsche M, Not all T cell synapses are built the same way, Trends in Immunology, 2019.
37. Skamrahl M, Colin-York H, Barbieri L, and Fritzsche M, Simultaneous Quantification of the Interplay Between Molecular Turnover and Cell Mechanics by AFM–FRAP, Small, 2019.
36. Colin-York H, Javanmardi Y, Barbieri L, Li Di, Korobchevskaya K, Guo Y, Hall C, Taylor A, Khuon S, Sheridan G, Chew TL, Li D, Moeendarbary E, and Fritzsche M, Spatiotemporally Super-resolved Volumetric Traction Force Microscopy, Nano Letters, 2019.
35. Colin-York H, Javanmardi Y, Skamrahl M, Kumari S, Chang VT, Khuon S, Taylor A, Chew TL, Betzig E, Moeendarbary E, Cerundolo V, Eggeling C, and Fritzsche M, Cytoskeletal Control of Antigen-Dependent T Cell Activation, Cell Reports, 2019.
34. Colin-York H, Li D, Korobchevskaya K, Chang VT, Betzig E, Eggeling C, and Fritzsche M, Cytoskeletal actin patterns shape mast cell activation, Nature Communications Biology, 2019.
33. Michaels YS, Barnkob MB, Barbosa H, Baeumler TA, Thompson MK, Andre V, Colin-York H, Fritzsche M, Gileadi U, Sheppard HM, Knapp DJHF, Milne TA, Cerundolo V & Fulga TA, Precise tuning of gene expression levels in mammalian cells, Nature Communications, 2019.
2018
32. Colin-York H, Eggeling C, and Fritzsche M, "Super-resolution Traction Force Microscopy", in the special issue "The 2018 correlative microscopy techniques roadmap, Journal Physics D, 2018.
31. Fritzsche M, Li D, Colin-York H, Chang VT, Moeendarbary E, Felce JH, Sezgin E, Charras GT, Betzig E, Eggeling C, Special Web Collection Active Matter, Nature, 2018.
30. Schneider F , Waithe D, Lagerholm BC , Shrestha D, Sezgin E , Eggeling C, and Fritzsche M, Statistical Analysis of Scanning Fluorescence Correlation Spectroscopy Data Differentiates Free from Hindered Diffusion, ACS Nano, 2018.
29. Colin-York H, Barbieri L, and Fritzsche M, Mechanical forces guide the biophysics of immune cells, Microscopy and analysis, 2018.
28. Fritzsche M, Michael L Dustin, Chapter 1 – Organization of Immunological Synapses and Kinapses, Book Chapter, Structural Biology in Immunology, Academic Press, 2018.
27. Gutowska-Owsiak D++, Bernardino de La Serna J++, Fritzsche M++, Naeem A , Podobas EI, Leeming M, Colin-York H, O’Shaughnessy R, Eggeling C, Ogg GS, Orchestrated control of filaggrin–actin scaffolds underpins cornification, Nature Cell Death & Disease, 2018 (++ co-first authored).
26. Santos AM++, Ponjavic A++, Fritzsche M++, Fernandes RA++, Bernardino de la Serna J, Wilcock MJ, Schneider F, Urbančič I, McColl J, Anzilotti C, Ganzinger KA, Aßmann M, Depoil D, Cornall RJ, Dustin ML, Klenerman D, Davis SJ, Eggeling C & Lee SF, Capturing resting T cells: the perils of PLL, Nature Immunology, 2018 (++ co-first authored).
2017
25. Colin-York H, Fritzsche M, The future of traction force microscopy, Current Opinion in Biomedical Engineering, 2017.
24. Lee AM++, Colin-York H++, Fritzsche M, CalQuo2 : Automated Fourier-space, population-level quantification of global intracellular calcium responses, Scientific Reports, 2017 (++ co-first authored).
23. Korobchevskaya K, Lagerholm BC, Colin-York H, and Fritzsche M, Exploring the Potential of Airyscan Microscopy for Live Cell Imaging, Photonics, 2017.
22. Fritzsche M, Fernandes RA, Chang VT, Colin-York H, Clausen MP, Felce JH, Galiani S, Erlenkämper C, Santos AM, Heddleston JM, Pedroza-Pacheco I, Waithe D, J. B. de la Serna, Lagerholm BC, Liu TL, Chew TL, Betzig E, Davis SJ, Eggeling C, Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation. Science Advances, 2017.
21. Fritzsche M, Self-organizing actin patterns shape cytoskeletal cortex organization, Communicative & Integrative Biology, 2017.
20. Colin-York H, Eggeling C, Fritzsche M, Dissection of mechanical force in living cells by super-resolved traction force microscopy, Nature Protocols, 2017.
19. Clausen MP, Colin-York H, Schneider F, Eggeling C, Fritzsche M, Dissecting the actin cortex density and membrane-cortex distance in living cells by super-resolution microscopy, Journal of Physics D, 2017.
18. Fritzsche M, Li D, Colin-York H, Chang VT, Moeendarbary E, Felce JH, Sezgin E, Charras GT, Betzig E, Eggeling C, Self-organizing actin patterns shape membrane architecture but not cell mechanics, Nature Communications, 2017.
2016
17. Stanly TA, Fritzsche M, Banerji S, Garcia E, de la Serna JB, Jackson DG, Eggeling C, Critical importance of appropriate fixation conditions for faithful imaging of receptor microclusters, Biology Open, 2016.
16. Fritzsche M, Erlenkämper C, Moeendarbary E, Charras G, Kruse K, Actin kinetics shapes cortical network structure and mechanics, Science Advances, 2016.
15. Colin-York H, Shrestha D, Felce JH, Waithe D, Moeendarbary E, Davis SJ, Eggeling C, and Fritzsche M, Super-resolved Traction Force Microscopy (STFM), Nano Letters, 2016.
2015
14. Fritzsche M & Eggeling C. POTENTIAL OF SUPER-RESOLUTION., Pan-European Networks: Science & Technology, 2015.
13. Fritzsche M, Fernades RA, Colin-York H, Santos AM, Lee S, Lagerholm BC, Davis SJ, and Eggeling C, CalQuo: automated, simultaneous single-cell and population-level quantification of intracellular Ca 2+ responses, Scientific Reports, 2015.
12. Malinova D, Fritzsche M, Nowosad CR, Armer CM, Munro PM, Blundell MP, Charras GT, Tolar P, Bouma G, and Thrasher AJ, WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts, Journal of Leukocyte Biology, 2015.
11. Fritzsche M & Charras GT, Dissecting protein reaction dynamics in living cells by fluorescence recovery after photobleaching, Nature Protocols, 2015.
2014
10. Fritzsche M, Thorogate R, and Charras GT, Quantitative Analysis of Ezrin Turnover Dynamics in the Actin Cortex, Biophysical Journal, 2014.
9. Lewalle A, Fritzsche M, Wilson K, Thorogate R, Duke T, and Charras GT, A phenomenological density-scaling approach to lamellipodial actin dynamics, Royal Society Interface Focus, 2014.
8. Clausen MP, Galiani S, de la Serna JB, Fritzsche M, Chojnacki J, Gehmlich K, Lagerholm BC, Eggeling C. Pathways to optical STED microscopy, NanoBioImaging, 2014.
2013
7. Bovellan M, Romeo Y, Fritzsche M, Moulding D, Thorogate R, Jegou A, Trasher AJ, Romet-Lemonne G, Roux P, Paluch EK, and Charras G, Cellular Control of Cortical Actin Nucleation, Current Biology, 2014.
6. Wilson K, Lewalle A, Fritzsche M, Thorogate R, Duke T, and Charras GT. Mechanisms of leading edge protrusion in interstitial migration, Nature Communications, 2013.
5. Fritzsche M, Lewalle A, Duke T, and Charras GT. Analysis of turnover dynamics of the submembranous actin cortex, Molecular Biology of the Cell, 2013 (Faculty 1000).
2012
4. Moeendarbary E, Valon L, Fritzsche M, Harris AR, Moulding DA, A. J Thrasher, E. Stride, L Mahadevan at al, and G.T. Charras, Cellular rheology and hydraulics, Nature Materials, 2012.
3. Soerensen PM, Iacob EM, Fritzsche M, Engen JR, Brieher M, Charras G, and Eggert US, The natural product cucurbitacin inhibits depolymerization of actin filaments by a unique mechanism, ACS Chemical Biology, 2012.
2. Worth A, Metelo JI, Bouma G, Fritzsche M, and Burns SOI, Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration, Blood, 2012.
2010
1. Bovellan M++, Fritzsche M++, Stevens C, Charras G. Death‐associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death, FEBS Letter, 2010 (++ co-first authored).
